Through the early 1960s and 1970s, he made low-budget thrillers opposite starlets. In 1962, he appeared in an English-language film titled Tarzan Goes to India opposite Simi Garewal. His first big hit was in 1965, with Phani Majumdar's Oonche Log (1965), where he was pitted against screen idols Raaj Kumar and Ashok Kumar; he gave a notable sensitive performance. It was followed by some more small budget hit films like Samson, Ek Sapera Ek Lootera and Char Darvesh. Again, in the same year, he played a sacrificing lover in the mushy musical Arzoo, starring Sadhana. With this, Khan earned his entry into A-list second leads. With the film Aadmi Aur Insaan (1969), Khan won his first Filmfare award for Best Actor in a Supporting Role. His other hit films were Khotey Sikkay, Geeta Mera Naam, Pyasi Sham, Shankar Shambhu and Safar. He appeared alongside his real-life brother Sanjay Khan in the hit films Upaasna (1967), Mela (1971) and Nagin (1976).
Throughout the late 1970s and 1980s, he was a leading Bollywood star, directing and starring in many of his films. He also starred in the Punjabi film Bhagat Dhanna Jat (1974). The 1980 film Qurbani, with Zeenat Aman, was the biggest hit of his career and launched the singing career of iconic Pakistani pop singer Nazia Hassan, with her memorable track "Aap Jaisa Koi". In 1986, he directed and starred in Janbaaz, a box office hit, which some consider to be one of his best movies, featured an all-star cast and possessed great songs and excellent cinematography. In 1988, he directed and starred in Dayavan, which was a remake of an Indian Tamil film titled Nayagan. After directing and starring in Yalgaar (1992), he took a long break from acting for 11 years.
In 2003, he made his acting comeback as well as produced and directed Janasheen, which also starred his son Fardeen.
He died from lung cancer on 27 April 2009 at the age of 69. During his illness he returned to rest at his farmhouse in Bangalore.
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